The doctors and the Center for Disease Control try to find an antidote to the deadly virus; Leanne makes a life-changing decision; Jesse welcomes a new batch of residents.
The Devil’s Workshop
The ER is quarantined when a viral outbreak jeopardizes the lives of the doctors and patients; a young girl who Leanne bonded with a year ago when she lost her father, returns to Angels Memorial.
Mario risks his own life when he follows Willis to a construction site where two brothers are trapped on a crane 300 feet above the ground; the wife of an orthopedist from Angels Memorial is brought into the ER with mysterious injuries.
While taking on a new role as the hospital chaplain, Guthrie considers undergoing a risky surgery to treat his Parkinson’s; victims of an apartment fire arrive at Angels Memorial Hospital.
One in a Million
Defying Campbell’s orders, Leanne uses the hospital helicopter to reunite a family one last time; Willis and Noa find a cellphone app to help them communicate with an autistic girl.
Mario decides to confront Angus; Christa is faced with a surprise; Dr. Mark Taylor returns to help Leanne find money in the budget for the nurses.
Christa must ignore her personal feelings as she and Grace treat a patient who says he was abused at a camp for troubled teenagers; Campbell surprises Grace by asking her out on a date.
Christa feels insecure when Neal’s ex-girlfriend (Meagan Good) returns to the hospital after a year of volunteering in Haiti; New York Giants wide receiver Odell Beckham Jr. wants his stubborn high school football coach to have a life-saving surgery.
Diagnosis of Exclusion
When a violent incident inside the hospital leads to grave injuries, the doctors are questioned; Christa and Neal disclose their relationship to human resources.
The Fifth Stage
Leanne visits a prison to finally confront the drunk driver who killed her family. Meanwhile, Malaya begins to feel uncomfortable around her patient.